5-Amino-1MQ
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). By blocking NNMT, it aims to enhance cellular energy metabolism, increase NAD+ availability, and counteract age-related metabolic decline.
Structure
Synthetic, quinoline-based small molecule
Designed for selective inhibition of NNMT
Small-molecule pharmacological agent, not a peptide
Mechanism of Action
- NNMT Inhibition: Blocks the methylation of nicotinamide (NAM), reducing NAM consumption.
- NAD+ Boost: Increases substrate availability for the NAD+ salvage pathway, elevating cellular NAD+ levels, which support energy production and sirtuin-mediated longevity pathways.
- Methylation Pool Enhancement: Frees methyl groups (SAMe), potentially improving overall cellular methylation processes.
- Metabolic Enhancement: Higher NAD+ levels improve mitochondrial function, support energy metabolism, and reduce fat accumulation, reversing aspects of the aged metabolic phenotype.
Indications
(Preclinical and investigational uses):
Obesity & Metabolic Syndrome: Potential to improve metabolic health and reduce adiposity.
Age-Related Mitochondrial Decline: Supports mitochondrial function and energy metabolism in aging tissues.
Non-Alcoholic Fatty Liver Disease (NAFLD): Preclinical studies suggest potential for reducing hepatic fat accumulation.
Low NAD+ Conditions: Investigated for disorders associated with impaired NAD+ metabolism.
5-Amino-1MQ
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). By blocking NNMT, it aims to enhance cellular energy metabolism, increase NAD+ availability, and counteract age-related metabolic decline.
Structure
Synthetic, quinoline-based small molecule
Designed for selective inhibition of NNMT
Small-molecule pharmacological agent, not a peptide
Mechanism of Action
- NNMT Inhibition: Blocks the methylation of nicotinamide (NAM), reducing NAM consumption.
- NAD+ Boost: Increases substrate availability for the NAD+ salvage pathway, elevating cellular NAD+ levels, which support energy production and sirtuin-mediated longevity pathways.
- Methylation Pool Enhancement: Frees methyl groups (SAMe), potentially improving overall cellular methylation processes.
- Metabolic Enhancement: Higher NAD+ levels improve mitochondrial function, support energy metabolism, and reduce fat accumulation, reversing aspects of the aged metabolic phenotype.
Indications
(Preclinical and investigational uses):
Obesity & Metabolic Syndrome: Potential to improve metabolic health and reduce adiposity.
Age-Related Mitochondrial Decline: Supports mitochondrial function and energy metabolism in aging tissues.
Non-Alcoholic Fatty Liver Disease (NAFLD): Preclinical studies suggest potential for reducing hepatic fat accumulation.
Low NAD+ Conditions: Investigated for disorders associated with impaired NAD+ metabolism.