BRONCHOGEN
Bronchogen is a synthetic tetrapeptide (Ala-Glu-Asp-Leu) bioregulator developed to support respiratory health by targeting bronchial and lung tissue. It regulates gene expression to promote repair of bronchial epithelial cells, reduce inflammation, and enhance lung function, potentially benefiting conditions like chronic obstructive pulmonary disease (COPD), bronchitis, and asthma. Preclinical studies indicate Bronchogen may improve respiratory parameters, reduce oxidative stress, and support recovery from respiratory infections. While it shows promise in integrative medicine, particularly in Russia, further clinical trials are necessary to validate its efficacy and establish its role in standard respiratory care
CHONLUTEN
Chonluten is a short bioregulator tripeptide (Glu-Asp-Gly) derived from lung tissue, designed to support pulmonary health, promote lung tissue regeneration, and modulate gene expression related to inflammation and antioxidant activity. It stimulates repair of lung parenchyma and bronchial tissues, reduces airway inflammation, enhances local immune defense, and may protect against chronic respiratory conditions such as COPD, asthma, and bronchitis. Chonluten acts on genes including c-FOS, HSP70, COX-2, and TNF-alpha, regulating cell proliferation, stress responses, and tissue repair, with secondary activity in the gastrointestinal tract. Administered orally or subcutaneously, it is well-tolerated with minimal side effects and shows potential as an adjuvant for improving respiratory function, supporting recovery, and protecting lung tissue from chronic inflammatory damage.
CARDIOGEN
Cardiogen is a synthetic tetrapeptide (H-Ala-Glu-Asp-Arg-OH) classified as a bioregulator peptide, primarily researched for its potential to support cardiovascular health by targeting fibroblasts, the cells responsible for tissue repair and scar formation. Developed in Russia under Dr. Vladimir Khavinson, it is believed to stimulate cardiomyocyte proliferation, reduce scar tissue formation by modulating fibroblast activity, and lower p53 protein expression to inhibit apoptosis in cardiac cells, potentially improving outcomes in conditions like heart attack, hypertension, and chronic heart failure. Additionally, studies suggest Cardiogen may enhance the effects of standard treatments and could have anti-proliferative effects on tumor cells, particularly in sarcoma, by promoting apoptosis in these cells.
CARTALAX
Cartalax is a synthetic tripeptide bioregulator (Ala-Glu-Asp, AED) developed by the St. Petersburg Institute of Bioregulation and Gerontology, primarily targeting fibroblasts to support cartilage, bone, and connective tissue health. It modulates gene expression to enhance cell proliferation (via increased Ki-67 and CD98hc expression), reduce apoptosis (by decreasing p53, p16, p21, and caspase-3), and inhibit matrix metalloproteinase-9 (MMP-9) synthesis, which is linked to tissue breakdown during aging. Research suggests Cartalax promotes tissue regeneration, improves microcirculation, and enhances extracellular matrix components like collagen and carnosine, making it effective for conditions such as osteoarthritis, spinal osteochondrosis, osteoporosis, and post-injury recovery. As a geroprotective peptide, it shows promise in slowing cellular aging and supporting musculoskeletal health, but its use is primarily experimental, with clinical applications limited to integrative medicine pending further human trials.
CORTAGEN
Cortagen is a synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Pro) that primarily targets the brain and central nervous system to regulate inflammatory responses and support neuroprotection and recovery post-injury. It modulates gene expression to reduce DNA condensation, restoring youthful gene activity, and decreases lipid peroxidation to combat oxidative stress, particularly in neural and cardiac tissues. Research indicates Cortagen stimulates interleukin-2 expression to regulate immune function, reducing autoimmune reactions, and shows promise in treating ischemic brain injuries and age-related neurodegeneration. While preclinical studies highlight its potential to enhance brain recovery and reduce senescence, Cortagen’s clinical use remains limited, and more comprehensive human trials are needed to validate its therapeutic benefits.
EPITALON
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from epithalamin, a naturally occurring peptide produced in the pineal gland, developed for its potential anti-aging properties. It works primarily by activating telomerase, which maintains and elongates telomeres to protect chromosomes and slow cellular aging. In addition, Epithalon regulates circadian rhythms by enhancing melatonin production, reduces oxidative stress, and modulates gene expression related to DNA repair, stress response, and aging. These mechanisms collectively support delayed cellular aging, improved sleep quality, strengthened immune function, and neuroprotection, including ocular health. Administered primarily via subcutaneous injection, Epithalon has demonstrated minimal side effects and is generally well-tolerated, making it a promising candidate for longevity and regenerative research.
LIVAGEN
Livagen is a tetrapeptide bioregulator (sequence Lys-Glu-Asp-Ala) primarily studied for its effects on the immune system, liver, and gastrointestinal tract. It works by decondensing chromatin, which increases gene expression and may restore a more “youthful” profile in cells. Research suggests Livagen can activate lymphocytes, enhance immune function, and improve protein synthesis, supporting overall organ health and resilience. It is mainly used in experimental and research contexts and is not approved for human therapeutic use.
OVAGEN
Ovagen is a synthetic tripeptide bioregulator (Glu-Asp-Leu) targeting the liver and gastrointestinal tract, where it regulates gene expression to normalize cellular function and promote tissue repair. It reduces long-term fibrosis in the liver, protects the GI mucosal layer from damage caused by antibiotics, environmental toxins, or chemotherapy, and may inhibit HIV replication, making it of interest for liver disease, inflammatory conditions, and postoperative recovery. Preclinical studies suggest Ovagen resets age-related DNA changes in liver fibroblasts and GI mucosal cells, enhancing their functionality and reducing senescence. Available as a dietary supplement in tablet or capsule form, Ovagen is primarily used in integrative medicine, but its clinical applications are limited, with ongoing research needed to validate its efficacy and safety in broader medical contexts.
PINEALON
Pinealon is a synthetic tripeptide bioregulator (Glu-Asp-Arg) designed to support brain health by targeting the pineal gland and central nervous system, where it interacts directly with DNA to modulate gene expression and protect neurons from hypoxia and oxidative stress. It is believed to enhance cognitive functions such as memory, learning, and attention, while also regulating circadian rhythms and drug metabolism, potentially benefiting conditions like stroke, traumatic brain injury, and age-related cognitive decline. Studies, primarily preclinical, suggest Pinealon reduces reactive oxygen species accumulation, inhibits apoptosis via lowered caspase-3 and p53 activity, and promotes telomere lengthening for anti-aging effects. Its use is largely experimental, with clinical applications limited to integrative medicine, requiring further research to confirm safety and efficacy in humans.
PROSTAMAX
Prostamax: Prostamax is a synthetic tetrapeptide bioregulator (Lys-Glu-Asp-Pro) designed to support prostate health by modulating gene expression and influencing DNA condensation in prostate cells and lymphocytes. It promotes tissue repair, reduces inflammation, and mitigates sclerotic and atrophic processes, showing promise in treating chronic aseptic prostatitis and benign prostatic hyperplasia (BPH) by alleviating symptoms like swelling, vascular congestion, and urinary dysfunction. Research in rat models and cell cultures indicates Prostamax enhances chromatin decondensation, activates repressed genes, and supports cellular longevity, potentially offering anti-aging benefits beyond the prostate. While preclinical studies highlight its efficacy in reducing prostate inflammation and improving glandular function, its clinical use remains largely experimental, requiring further human trials to confirm safety and therapeutic potential.
TESTAGEN
Testagen is a synthetic tetrapeptide (Lys-Glu-Asp-Gly) designed to support male reproductive health by targeting testicular cells and regulating testosterone production. It modulates gene expression to enhance spermatogenesis, improve hormonal balance, and support testicular function, potentially aiding in conditions like male infertility, low testosterone, and age-related reproductive decline. Studies, primarily from Russian research, suggest Testagen may improve sperm quality, libido, and overall reproductive health while also reducing oxidative stress in testicular tissue. Its use is largely in integrative medicine, and further clinical evidence is needed to establish its efficacy and safety.
VESUGEN
Vesugen is a synthetic tripeptide bioregulator (Lys-Glu-Asp) designed to support vascular health by targeting endothelial cells to improve blood vessel integrity and function. It modulates gene expression to stimulate angiogenesis, enhance microcirculation, and reduce vascular inflammation, making it a potential therapeutic for conditions such as atherosclerosis, hypertension, and peripheral vascular disease. Preclinical studies suggest Vesugen promotes endothelial repair, reduces oxidative stress, and supports recovery from ischemic events by normalizing cellular function and enhancing vascular resilience. Primarily developed through Russian research under Dr. Vladimir Khavinson, Vesugen is used in integrative medicine for cardiovascular support and anti-aging, but its clinical application remains limited, with further human trials needed to confirm its safety and efficacy.
VILON
Vilon is a synthetic dipeptide (Lys-Glu) bioregulator with broad applications in tissue repair and anti-aging, targeting multiple cell types to promote regeneration and reduce age-related decline. It works by modulating gene expression to enhance protein synthesis, reduce apoptosis, and improve cellular repair mechanisms, potentially benefiting conditions like wound healing, organ degeneration, and immune dysfunction. Studies suggest Vilon may extend lifespan, improve metabolic function, and inhibit tumor growth by regulating cellular stress responses. Widely studied in Russia, its versatility makes it a cornerstone of bioregulator therapy, though global clinical validation remains limited.
